作者
Huan Meng*, Min Xue*, Tian Xia*, Yan-Li Zhao, Fuyuhiko Tamanoi, J Fraser Stoddart, Jeffrey I Zink, Andre E Nel
发表日期
2010/8/18
期刊
Journal of the American Chemical Society
卷号
132
期号
36
页码范围
12690-12697
出版商
American Chemical Society
简介
Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of β-cyclodextrin (β-CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB-31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of …
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H Meng, M Xue, T Xia, YL Zhao, F Tamanoi… - Journal of the American Chemical Society, 2010