作者
Huan Meng, Min Xue, Tian Xia, Zhaoxia Ji, Derrick Y Tarn, Jeffrey I Zink, Andre E Nel
发表日期
2011/4/27
期刊
ACS Nano
卷号
5
期号
5
页码范围
4131-4144
出版商
American Chemical Society
简介
A key challenge for improving the efficacy of passive drug delivery to tumor sites by a nanocarrier is to limit reticuloendothelial system uptake and to maximize the enhanced permeability and retention effect. We demonstrate that size reduction and surface functionalization of mesoporous silica nanoparticles (MSNP) with a polyethyleneimine–polyethylene glycol copolymer reduces particle opsonization while enhancing the passive delivery of monodispersed, 50 nm doxorubicin-laden MSNP to a human squamous carcinoma xenograft in nude mice after intravenous injection. Using near-infrared fluorescence imaging and elemental Si analysis, we demonstrate passive accumulation of ∼12% of the tail vein-injected particle load at the tumor site, where there is effective cellular uptake and the delivery of doxorubicin to KB-31 cells. This was accompanied by the induction of apoptosis and an enhanced rate of tumor …
学术搜索中的文章
H Meng, M Xue, T Xia, Z Ji, DY Tarn, JI Zink, AE Nel - ACS nano, 2011