作者
Melanie L Bell, Mallorie Fiero, Nicholas J Horton, Chiu-Hsieh Hsu
发表日期
2014/12
来源
BMC medical research methodology
卷号
14
页码范围
1-8
出版商
BioMed Central
简介
Background
Missing outcome data is a threat to the validity of treatment effect estimates in randomized controlled trials. We aimed to evaluate the extent, handling, and sensitivity analysis of missing data and intention-to-treat (ITT) analysis of randomized controlled trials (RCTs) in top tier medical journals, and compare our findings with previous reviews related to missing data and ITT in RCTs.
Methods
Review of RCTs published between July and December 2013 in the BMJ, JAMA, Lancet, and New England Journal of Medicine, excluding cluster randomized trials and trials whose primary outcome was survival.
Results
Of the 77 identified eligible articles, 73 (95%) reported some missing outcome data. The median percentage of participants with a missing outcome was 9% (range 0 – 70%). The most commonly used …
学术搜索中的文章
ML Bell, M Fiero, NJ Horton, CH Hsu - BMC medical research methodology, 2014