作者
Martina C de Knegt, Jesper J Linde, Per E Sigvardsen, Thomas Engstrøm, Andreas Fuchs, Andreas K Jensen, Hanne Elming, J Tobias Kühl, Peter R Hansen, Dan E Høfsten, Henning Kelbæk, Børge G Nordestgaard, Jens D Hove, Lars V Køber, Klaus F Kofoed, Børge Nordestgaard, Mathias Sørgaard, Jakob Norsk, Daria Frestad, Mads Mejdahl, Marie Elming, Samuel Kiil Sørensen, Louise Hindsøe, Anna Foged Thomsen, Patricia Martens Udholm, Christian Pihl, Julia Nilsson, Christina Byrne, Andreas Dehlbæk Knudsen, Morten Haugen, Josefine Windfeld-Mathiasen, Yaffah Tamar Laura Wiegandt, Michael HC Pham, Christian Ballegaard, Kirsten Arnaa, Christina Møller, Kirsten Thrysøe, Gorm B Jensen, Walter Nielsen, Kirsten Trysøe, Tina Bock-Pedersen, Bettina Hansen, Lene Kløvgaard, Lene Holmvang, Steffen Helquist, Erik Jørgensen, Frans Petersen, Kari Saunamaki, Peter Clemmensen, Golnaz Sadjadieh, Peter Nørkjær Laursen, Christian Torp Petersen, Peter Riis Hansen, Gunnar Gislason, Ulrik Abildgaard, Jan Skov Jensen, Søren Galatius, Thomas Fritz-Hansen, Jan Bech, Christian Wachtell, Jan Kyst Madsen, Lærke Smedegaard, Cengiz Özcan, Merete Heitmann, Ida Hastrup Svendsen, Olav Wendelboe Nielsen, Ole Kristiansen, Andreas Fabricius Bjerre, Ulrik Dixen, Johnny Koertz Madsen, Gitte Gleerup Fornitz, Ilan Raymond, Jawdat Abdulla, Stig Lyngbæk, Rolf Steffensen, Birgit Jurlander, Charlotte Kragelund, Helena Dominguez, Morten Schou, Susette Therkelsen
发表日期
2024/3/1
期刊
Journal of Cardiovascular Computed Tomography
卷号
18
期号
2
页码范围
203-210
出版商
Elsevier
简介
Background
We examined obstructive and nonobstructive plaque volumes in populations with subclinical and clinically manifested coronary artery disease (CAD) using quantitative computed tomography (QCT).
Methods
855 participants with CAD (274 asymptomatic individuals, 254 acute chest pain patients without acute coronary syndrome (ACS), and 327 patients with ACS) underwent QCT of proximal coronary segments to assess participant-level plaque volumes of dense calcium, fibrous, fibrofatty, and necrotic core tissue.
Results
Nonobstructive (<50% stenosis) plaque volumes were greater than obstructive plaque volumes, irrespective of population (all p<0.0001): Asymptomatic individuals (mean (95% CI)): 218 [190-250] vs. 16 [12-22] mm3; acute chest pain patients without ACS: 300 [263-341] vs. 51 [41-62] mm3; patients with ACS: 370 [332-412] vs. 159 [139-182] mm3. After multivariable adjustment …
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MC de Knegt, JJ Linde, PE Sigvardsen, T Engstrøm… - Journal of Cardiovascular Computed Tomography, 2024