作者
Kaisa M Mäki-Petäjä, Joseph Cheriyan, Anthony D Booth, Frances C Hall, John Brown, Sharon ML Wallace, Mike J Ashby, Carmel M McEniery, Ian B Wilkinson
发表日期
2008/10/13
期刊
International journal of cardiology
卷号
129
期号
3
页码范围
399-405
出版商
Elsevier
简介
BACKGROUND
Recent in vitro studies suggest that inducible nitric oxide synthase (iNOS) activity mediates endothelial dysfunction. Rheumatoid arthritis (RA) is a chronic inflammatory condition and is associated with endothelial dysfunction and increased risk of cardiovascular disease. The aim of the study was to establish the contribution of iNOS to endothelial function.
METHODS
Forearm blood flow (FBF) was measured during intra-arterial infusions of acetylcholine (ACh), sodium nitroprusside (SNP), NG-monomethyl-l-arginine (l-NMMA) and aminoguanidine (AG) in 12 RA patients and 13 healthy control subjects. Levels of C-reactive protein (CRP) and myeloperoxidase (MPO) were assessed. FBF data are presented as mean percentage changes in the ratio (infused/control arm) of FBF±SEM.
RESULTS
FBF response to ACh was reduced in patients with RA compared to controls (179±29 v. 384±72 …
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