作者
Shayan Kassirian, Stephanie N Hinton, Sean Cuninghame, Rushil Chaudhary, Alla Iansavitchene, Kayvan Amjadi, Inderdeep Dhaliwal, Cady Zeman-Pocrnich, Michael A Mitchell
发表日期
2023/1/1
来源
Thorax
卷号
78
期号
1
页码范围
32-40
出版商
BMJ Publishing Group Ltd
简介
Background
Pleural fluid cytology is an important diagnostic test used for the investigation of pleural effusions. There is considerable variability in the reported sensitivity for the diagnosis of malignant pleural effusions (MPE) in the literature.
Objective
The purpose of this review is to determine the diagnostic sensitivity of pleural fluid cytology for MPE, both overall and by tumour type, to better inform the decision-making process when investigating pleural effusions.
Data sources
A literature search of EMBASE and MEDLINE was performed by four reviewers. Articles satisfying inclusion criteria were evaluated for bias using the QUADAS-2 tool.
Data extraction
For quantitative analysis, we performed a metaanalysis using a binary random-effects model to determine pooled sensitivity. Subgroup analysis was performed based on primary cancer site and meta-regression by year of publication.
Synthesis
Thirty-six studies with …
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S Kassirian, SN Hinton, S Cuninghame, R Chaudhary… - Thorax, 2023