作者
Robert H Pietrzak, Simon M Laws, Yen Ying Lim, Sophie J Bender, Tenielle Porter, James Doecke, David Ames, Christopher Fowler, Colin L Masters, Lidija Milicic, Stephanie Rainey-Smith, Victor L Villemagne, Christopher C Rowe, Ralph N Martins, Paul Maruff
发表日期
2017/1/1
期刊
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
卷号
2
期号
1
页码范围
45-52
出版商
Elsevier
简介
Background
Hypothalamic-pituitary-adrenal axis dysregulation, which is typically assessed by measuring cortisol levels, is associated with cognitive dysfunction, hippocampal atrophy, and increased risk for mild cognitive impairment and Alzheimer’s disease (AD). However, little is known about the role of hypothalamic-pituitary-adrenal axis dysregulation in moderating the effect of high levels of amyloid-β (Aβ+) on cognitive decline in the preclinical phase of AD, which is often protracted, and thus offers opportunities for prevention and early intervention.
Methods
Using data from a 6-year multicenter prospective cohort study, we evaluated the relation between Aβ level, plasma cortisol level, and cognitive decline in 416 cognitively normal older adults.
Results
Results revealed that Aβ+ older adults experienced faster decline than Aβ− older adults in all cognitive domains (Cohen’s d at 6-year assessment = 0.37–0.65 …
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RH Pietrzak, SM Laws, YY Lim, SJ Bender, T Porter… - Biological Psychiatry: Cognitive Neuroscience and …, 2017