作者
Gemma Cadby, Corey Giles, Phillip E Melton, Kevin Huynh, Natalie A Mellett, Thy Duong, Anh Nguyen, Michelle Cinel, Alex Smith, Gavriel Olshansky, Tingting Wang, Marta Brozynska, Mike Inouye, Nina S McCarthy, Amir Ariff, Joseph Hung, Jennie Hui, John Beilby, Marie-Pierre Dubé, Gerald F Watts, Sonia Shah, Naomi R Wray, Wei Ling Florence Lim, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Tenielle Porter, Michael Vacher, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Kevin Taddei, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin, Xianlin Han, Rima Kaddurah-Daouk, Ralph N Martins, John Blangero, Peter J Meikle, Eric K Moses
发表日期
2022/6/6
期刊
Nature communications
卷号
13
期号
1
页码范围
3124
出版商
Nature Publishing Group UK
简介
We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, involving 667 genomic regions (479 previously unreported), with validation in two independent cohorts. A meta-analysis revealed an additional 70 independent genomic regions associated with lipid species. We identified 134 lipid endophenotypes for CAD associated with 186 genomic loci. Associations between independent lipid-loci with coronary atherosclerosis were assessed in ∼456,000 individuals from the UK Biobank. Of the 53 lipid-loci that showed evidence of association (P < 1 × 10−3), 43 loci were …
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G Cadby, C Giles, PE Melton, K Huynh, NA Mellett… - Nature communications, 2022