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Background: The absolute risk of sexual HIV transmission on stable ART (HIV RNA viral load (VL)< 200 c/mL) from condomless sex is unknown. Current limited data are largely focusing on vaginal sex

Methodology: The international, observational multi-centre PARTNER study prospectively follows serodifferent couples (heterosexual (HT) and MSM) who had condomless penetrative anal or vaginal sex in the month prior to study entry, and where the HIV+ ve partner is on ART. Every 6 months, each partner completes a sexual behaviour questionnaire and the negative partner tests for HIV. Eligibility of follow-up time in this transmission rate analysis required: continued condomless sex; not using PEP or PrEP; and latest VL< 200 c/mL. For new diagnoses, phylogenetic analysis compared HIV-1 pol and env sequences by couple, after samples were anonymised. This planned analysis reports the rate of occurrence of …