作者
Eva Orviz, Anabel Negredo, Oskar Ayerdi, Ana Vázquez, Ana Muñoz-Gomez, Sara Monzón, Petunia Clavo, Angel Zaballos, Mar Vera, Patricia Sánchez, Noemi Cabello, Pilar Jiménez, Jorge A Pérez-García, Sarai Varona, Jorge Del Romero, Isabel Cuesta, Alberto Delgado-Iribarren, Montse Torres, Iñigo Sagastagoitia, Gustavo Palacios, Vicente Estrada, Maria Paz Sánchez-Seco, Juan Ballesteros, Begoña Baza, Juan Carlos Carrió, Cynthia Chocron, Giovanni Fedele, Cristina García-Amil, Laura Herrero, Reynaldo Homen, Alberto Mariano, Teresa Martínez-Burgoa, Francisca Molero, Maria Luisa Navarro, Maria José Núñez, Juncal Perez-Somarriba, Teresa Puerta, Javier Rodríguez-Añover, Esperanza Pérez Pastrana, Mercedes Jiménez, Leticia de la Vega, Jorge Vergas, Isabel Zarza
发表日期
2022/10/1
期刊
Journal of Infection
卷号
85
期号
4
页码范围
412-417
出版商
WB Saunders
简介
Background
Monkeypox is the most prevalent Orthopoxvirus zoonosis infection since the eradication of smallpox. The current multi-country outbreak involves five WHO regions affecting mainly Europe. Accurate clinical and virological aspects of the disease outside endemic areas are needed.
Methods
We performed an observational study of cases diagnosed in Madrid (Spain) (May/June 2022). Confirmation from vesicular lesions swabs, Orthopoxvirus real-time PCR, sequencing, phylogenetic analysis, and direct detection by Electron microscopy was performed. In addition, a structured epidemiological questionnaire was completed systematically to gather sociodemographic, clinical, and behavioral data from all confirmed cases.
Findings
We extracted data from 48 patients, all cisgender men. The median age was 35 years (IQR 29 – 44), and 87.5% were MSM. The most prevalent symptoms were the presence of …
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