作者
Bashdar Mahmud Hussen, Gelavizh Ahmadi, Havva Marzban, Maryam Ebadi Fard Azar, Saba Sorayyayi, Romina Karampour, Javid Sadri Nahand, Hazha Jamal Hidayat, Mohsen Moghoofei
发表日期
2021/1/1
期刊
Microbial pathogenesis
卷号
150
页码范围
104692
出版商
Academic Press
简介
Background
The high mortality rate of lung cancer can be justified that strong need to explore new aspect of tumor biology. Human papillomavirus (HPV) has been detected as risk factor for the development of lung cancer. The aim of this study was to determine the role of HPV and cellular/miRNAs genes expression in the epithelial-mesenchymal transition (EMT) and development of lung cancer.
Methods
In this case-control study, 109 lung cancer tissue and 52 controls were included. We analyzed the presence of HPV infection, its genotypes (in positive samples) and the expression of viral genes (E2, E6 and E7). Also, We examined the expression of celluar factors including (a) p53 and retinoblastoma (Rb) (as anti-carcinogenic genes), (b) EMT related genes, (c) selected miRNAs.
Results
Our results reported 51.4% and 23.1% of HPV genome in tumor tissues and control tissues samples, respectively. There was a …
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