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Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). Inflammation caused by immune cells destroy the myelin and then axon. CNS failure to complete repair results in permanent disabilities. Some types of stem cells have special potentials to repair these injuries and even cure MS. Neural crest stem cells with a mutual origin with CNS and the ability of differentiation to different types of neural cells can replace lost cells. They also increase survival and development of neurons by secreting neurotrophins. Mesenchymal stem cells have a high potential to identify affected areas and migrate to there. They reduce inflammation and autoimmune reactions by affecting on all types of immune cells. Mesenchymal stem cells change phenotypes of T cells from inflammatory form to anti-inflammatory form by decreasing of INF and increasing of IL4 production. It also increases regulatory T cells …