作者
Muneeb U Rehman, Nemat Ali, Summya Rashid, Tyan Jain, Sana Nafees, Mir Tahir, Abdul Quaiyoom Khan, Abdul Lateef, Rehan Khan, Oday O Hamiza, Syed Kazim, Wajhul Qamar, Sarwat Sultana
发表日期
2014/12/1
期刊
Pharmacological Reports
卷号
66
期号
6
页码范围
1050-1059
出版商
No longer published by Elsevier
简介
Background
Cisplatin is an effective and extensively used chemotherapeutic agent to treat range of malignancies, but its therapeutic use is limited because of dose-dependent nephrotoxicity and hepatotoxicity. Several published reports advocate that supplementation with antioxidant can influence cisplatin induced hepatic damage.
Method
In the present study the Wistar rats were subjected to concurrent prophylactic oral treatment of chrysin (25 and 50 mg/kg b.wt.) against the hepatotoxicity induced by intraperitoneal administration of cisplatin (7.5 mg/kg b.wt.). Efficacy of chrysin against the hepatotoxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities, histopathological changes and expression levels of molecular markers of inflammation.
Results
Chrysin ameliorated cisplatin-induced lipid peroxidation, xanthine oxidase activity, glutathione depletion, decrease in antioxidant (catalase …
学术搜索中的文章
MU Rehman, N Ali, S Rashid, T Jain, S Nafees, M Tahir… - Pharmacological Reports, 2014