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Household contacts of HBV‐related chronic liver disease patients constitute a high‐risk group for acquisition of HBV infection. Some of the HBsAg mutants are associated with liver disease and some are reported to be transmitted vertically. There is limited information on the horizontal transmission of Gly 145 Arg (G145R) mutant to related contacts. Its possible transmission to an unrelated third degree contact is reported in the present study. An HBV related chronic liver disease patient; the index patient, and his 11 household contacts were studied. This included four 1°, three 2°, one 3°, and a sexual contact. Surface gene sequencing including the “a” determinant region was carried out in HBV DNA+ve subjects. The sequences were aligned and compared for the homology. HBV DNA was found to be positive in one 1°, three 2°, and one 3° contact, besides the index patient. Histopathological studies revealed …