作者
Frédéric A Houssiau, Carlos Vasconcelos, David D'Cruz, Gian Domenico Sebastiani, Enrique de Ramon Garrido, Maria Giovanna Danieli, Daniel Abramovicz, Daniel Blockmans, Alessandro Mathieu, Haner Direskeneli, Mauro Galeazzi, Ahmet Gül, Yair Levy, Peter Petera, Rajko Popovic, Radmila Petrovic, Renato Alberto Sinico, Roberto Cattaneo, Josep Font, Geneviève Depresseux, Jean‐Pierre Cosyns, Ricard Cervera
发表日期
2004/12
期刊
Arthritis & rheumatism
卷号
50
期号
12
页码范围
3934-3940
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
In the Euro‐Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high‐dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low‐dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors.
Methods
Renal function was prospectively assessed quarterly in all 90 patients except 5 who were lost to followup. Survival curves were derived using the Kaplan‐Meier method.
Results
After a median followup of 73 months, there was no significant difference in the cumulative probability of end‐stage renal disease or doubling of the serum …
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FA Houssiau, C Vasconcelos, D D'Cruz, GD Sebastiani… - Arthritis & rheumatism, 2004