作者
Jérémie Sellam, Valérie Proulle, Astrid Jüngel, Marc Ittah, Corinne Miceli Richard, Jacques-Eric Gottenberg, Florence Toti, Joelle Benessiano, Steffen Gay, Jean-Marie Freyssinet, Xavier Mariette
发表日期
2009/10
期刊
Arthritis research & therapy
卷号
11
页码范围
1-11
出版商
BioMed Central
简介
Introduction
Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we investigated level of circulating MPs as a possible biomarker in primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
Methods
We measured plasma levels of total, platelet and leukocyte MPs by prothrombinase capture assay and flow cytometry in 43 patients with pSS, 20 with SLE and 24 with RA and in 44 healthy controls (HCs). Secretory phospholipase A2 (sPLA2) activity was assessed by fluorometry. Soluble CD40 ligand (sCD40L) and soluble P-selectin (sCD62P), reflecting platelet activation, were measured by ELISA.
Results
Patients with pSS showed increased plasma level of total …
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J Sellam, V Proulle, A Jüngel, M Ittah, C Miceli Richard… - Arthritis research & therapy, 2009