作者
Floriana Bulic‐Jakus, Ana Katusic Bojanac, Gordana Juric‐Lekic, Maja Vlahovic, Nino Sincic
发表日期
2016/3
来源
Wiley Interdisciplinary Reviews: Developmental Biology
卷号
5
期号
2
页码范围
186-209
出版商
John Wiley & Sons, Inc.
简介
A teratoma is a benign tumor containing a mixture of differentiated tissues and organotypic derivatives of the three germ layers, while a teratocarcinoma also contains embryonal carcinoma cells (EC cells). Experimental teratomas and teratocarcinomas have been derived from early mammalian embryos transplanted into the adult animal (ectopic sites). In the rat, the pluripotency of the transplanted epiblast was demonstrated and a quantifiable restriction of developmental potential persisted after subsequent transplantation of chemically defined cultivated postimplantation embryos. The rat is nonpermissive for teratocarcinoma development and rat pluripotent cell lines have been established only recently. Transplantation of mouse embryos, epiblast, or embryonic stem cells (mESCs) gave rise to teratocarcinomas. The pluripotency of reprogrammed human cells has been tested by a ‘gold standard’ trilaminar teratoma …
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F Bulic‐Jakus, A Katusic Bojanac, G Juric‐Lekic… - Wiley Interdisciplinary Reviews: Developmental …, 2016