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Pollution with heavy metal is one of the most important environmental problems today, since various industries and human activities produce and discharge wastes containing different heavy metals into the environment. Thus, metal as a kind of resource is becoming shortage, it also brings about serious environmental pollution, threatening human and ecosystem health. Biosorption is considered as a feasible alternative for removing heavy metals from the environment, which utilizes various natural materials of biological origin, including bacteria, fungi, yeast, algae as sorbents. The first major challenge for the biosorption field was to select the most promising types of biomass from an extremely large pool of readily available and inexpensive biomaterials. In the field of biosorption, yeasts have proved to be efficient sorbents and many researches are reported and reviewed findings on the removal of heavy metal ions. Due to their unicellular nature and high growth rate, the studies have clearly demonstrated that yeasts can be used for trace enrichment of metal ions in aquatic environments. The paper analyses some theoretical and practical aspects on the topic of biosorption and specifies the main features involved in the biosorption of heavy metals when yeasts are used as sorbent, also providing some practical examples.