作者
Jens Henrichs, Jacoba J Bongers-Schokking, Jacqueline J Schenk, Akhgar Ghassabian, Henk G Schmidt, Theo J Visser, Herbert Hooijkaas, Sabine MPF de Muinck Keizer-Schrama, Albert Hofman, Vincent VW Jaddoe, Willy Visser, Eric AP Steegers, Frank C Verhulst, Yolanda B De Rijke, Henning Tiemeier
发表日期
2010/9/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
95
期号
9
页码范围
4227-4234
出版商
Oxford University Press
简介
Context: Thyroid hormones are essential for neurodevelopment from early pregnancy onward. Yet population-based data on the association between maternal thyroid function in early pregnancy and children’s cognitive development are sparse.
Objective: Our objective was to study associations of maternal hypothyroxinemia and of early pregnancy maternal TSH and free T4 (FT4) levels across the entire range with cognitive functioning in early childhood.
Design and Setting: We conducted a population-based cohort in The Netherlands.
Participants: Participants included 3659 children and their mothers.
Main Measures: In pregnant women with normal TSH levels at 13 wk gestation (sd = 1.7), mild and severe maternal hypothyroxinemia were defined as FT4 concentrations below the 10th and 5th percentile, respectively. Children’s expressive vocabulary at 18 months …
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J Henrichs, JJ Bongers-Schokking, JJ Schenk… - The Journal of Clinical Endocrinology & Metabolism, 2010