作者
Alexandru Mester, Lidia Ciobanu, Marian Taulescu, Dragos Apostu, Ondine Lucaciu, Gabriela Adriana Filip, Vasile Feldrihan, Emilia Licarete, Aranka Ilea, Andra Piciu, Daniel Oltean‐Dan, Iuliu Scurtu, Cristian Berce, Radu Septimiu Campian
发表日期
2019/8
期刊
Journal of Periodontology
卷号
90
期号
8
页码范围
911-919
简介
Background
The aim was to assess the effects of periodontal disease in promoting liver fibrosis in a rat model of ligature‐induced periodontitis.
Methods
Twenty‐four Wistar rats were divided into four groups: control (CTRL), experimental periodontitis group at day 7 (PER7), at day 14 (PER14), at day 21 (PER21). Experimental periodontitis was induced by the placement of a silk ligature around mandibular incisors. The following parameters were assessed: gingival index, tooth mobility; liver status, and portal vein caliber by ultrasound examination; bone retraction, bone mineral density (BMD), bone volume/tissue volume (BV/TV) by micro‐CT analysis; aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT); oxidative stress (malondialdehyde [MDA], reduced glutathione/oxidative glutathione ratio [GSH/GSSG]), and matrix metalloproteinase‐8 (MMP‐8) levels; and histopathological evaluation of …
学术搜索中的文章
A Mester, L Ciobanu, M Taulescu, D Apostu, O Lucaciu… - Journal of Periodontology, 2019