作者
Harald Wajant
发表日期
2002/5/31
来源
Science
卷号
296
期号
5573
页码范围
1635-1636
出版商
American Association for the Advancement of Science
简介
Apoptosis and related forms of cell death have central importance in development, homeostasis, tumor surveillance, and the function of the immune system. Apoptosis is initiated by two principal pathways. The intrinsic pathway emerges from mitochondria, whereas the extrinsic pathway is activated by the ligation of death receptors. This Viewpoint introduces the basic mechanisms of the extrinsic pathway, using the example of the prototypical death receptor Fas and its role in apoptosis, but it also points out the increasingly understood importance of this receptor as a non-apoptotic signal transducer.
引用总数
学术搜索中的文章