作者
Kai Wang, Quan-Xin Long, Hai-Jun Deng, Jie Hu, Qing-Zhu Gao, Gui-Ji Zhang, Chang-Long He, Lu-Yi Huang, Jie-Li Hu, Juan Chen, Ni Tang, Ai-Long Huang
发表日期
2021/8/1
期刊
Clinical Infectious Diseases
卷号
73
期号
3
页码范围
e531-e539
出版商
Oxford University Press
简介
Background
Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed vaccine or specific antiviral agents for therapy. Little is known about the longitudinal dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific neutralizing antibodies (NAbs) in patients with COVID-19.
Methods
Blood samples (n = 173) were collected from 30 patients with COVID-19 over a 3-month period after symptom onset and analyzed for SARS-CoV-2–specific NAbs using the lentiviral pseudotype assay, coincident with the levels of IgG and proinflammatory cytokines.
Results
SARS-CoV-2–specific NAb titers were low for the first 7–10 days after symptom onset and increased after 2–3 weeks. The median peak time for NAbs was 33 days (interquartile range [IQR], 24–59 days) after symptom onset. NAb titers in 93.3% (28/30) of the …
学术搜索中的文章
K Wang, QX Long, HJ Deng, J Hu, QZ Gao, GJ Zhang… - Clinical Infectious Diseases, 2021