作者
Guillermo Ruiz-Irastorza, Manuel Ramos-Casals, Pilar Brito-Zeron, Munther A Khamashta
发表日期
2010/1/1
来源
Annals of the rheumatic diseases
卷号
69
期号
01
页码范围
20-28
出版商
BMJ Publishing Group Ltd
简介
Background
Antimalarial drugs (AMs), chloroquine (CQ) and hydroxychloroquine (HCQ), are frequently withdrawn in patients with lupus with either severe or remitting disease. However, additional effects beyond immunomodulation have been recently described. The aim of the present work was to analyse all the published evidence of the beneficial and adverse effects of AM therapy in systemic lupus erythematosus (SLE).
Methods
A systematic review of the English literature between 1982 and 2007 was conducted using the MEDLINE and EMBASE databases. Randomised controlled trials (RCTs) and observational studies were selected. Case reports were excluded except for toxicity reports. The GRADE system was used to analyse the quality of the evidence.
Results
A total of 95 articles were included in the systematic review. High levels of evidence were found that AMs prevent lupus flares and increase long-term …
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