作者
Fabricio Almeida-Silva, Thiago M Venancio
发表日期
2022/8/24
期刊
in silico Plants
卷号
4
期号
2
页码范围
diac018
简介
Although genome-wide association studies (GWAS) identify variants associated with traits of interest, they often fail in identifying causative genes underlying a given phenotype. Integrating GWAS and gene coexpression networks can help prioritize high-confidence candidate genes, as the expression profiles of trait-associated genes can be used to mine novel candidates. Here, we present cageminer, an R package to prioritize candidate genes through the integration of GWAS and coexpression networks. Genes are considered high-confidence candidates if they pass all three filtering criteria implemented in cageminer, namely physical proximity to (or linkage disequilibrium with) single-nucleotide polymorphisms (SNPs), coexpression with known trait-associated genes, and significant changes in expression levels in conditions of interest. Prioritized candidates can also be scored and ranked to select targets for …
引用总数
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