作者
Paul Gallo, Lu Mao, Vivian H Shih
发表日期
2014/9/3
期刊
Journal of Biopharmaceutical Statistics
卷号
24
期号
5
页码范围
976-993
出版商
Taylor & Francis
简介
A feature increasingly utilized in clinical trial practice is to allow a study to stop early when it seems unlikely to achieve its primary efficacy objectives. This is commonly referred to as stopping for futility, and can be motivated by ethical and financial considerations. A number of methods for addressing futility have been described in the literature, including rules based upon conditional power, predictive probability, beta spending functions, and others. We consider futility stopping from the point of view of quantifying and providing an objective sensible balance between risks of incorrect decisions (e.g., stopping trials which should continue, and continuing trials which should stop), and discuss how specific considerations within a trial can lead to choice of a sensible scheme. This approach is not specific to any particular scales in the literature such as those just mentioned, and we describe interrelationships among criteria …
引用总数
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学术搜索中的文章
P Gallo, L Mao, VH Shih - Journal of biopharmaceutical statistics, 2014