作者
Anne F Rositch, Lu Mao, Michael G Hudgens, Stephen Moses, Kawango Agot, Danielle M Backes, Edith Nyagaya, Peter JF Snijders, Chris JLM Meijer, Robert C Bailey, Jennifer S Smith
发表日期
2014/3/13
期刊
AIDS (London, England)
卷号
28
期号
5
页码范围
745-752
出版商
NIH Public Access
简介
Objectives:
There are very few data from men on the risk of HIV acquisition associated with penile human papillomavirus (HPV) infection and no data on the potential modifying effect of male circumcision. Therefore, this study evaluated whether HPV is independently associated with risk of HIV.
Design:
A cohort study of HPV natural history nested within a randomized control trial of male circumcision to reduce HIV incidence in Kisumu, Kenya.
Methods:
Prospective data from 2519 men were analyzed using 6-month discrete-time Cox models to determine if HIV acquisition was higher among circumcised or uncircumcised men with HPV compared to HPV-uninfected men.
Results:
Risk of HIV acquisition was nonsignificantly increased among men with any HPV [adjusted hazard ratio (aHR) 1.72; 95% confidence interval (CI) 0.94–3.15] and high-risk HPV (aHR 1.92; 95% CI 0.96–3.87) compared to HPV-uninfected men, and …
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AF Rositch, L Mao, MG Hudgens, S Moses, K Agot… - Aids, 2014