作者
Xinyuan He, Bin Ma, Yan Chen, Jiantao Guo, Wei Niu
发表日期
2022
期刊
Chemical Communications
卷号
58
期号
39
页码范围
5897-5900
出版商
Royal Society of Chemistry
简介
Protein tyrosine phosphorylation plays a critical role in signal transduction. We report the genetic incorporation of a phosphotyrosine (pTyr) analog, p-carboxymethyl-L-phenylalanine (CMF), into proteins in mammalian cells. This nonhydrolyzable pTyr analog can facilitate biological studies by removing complications caused by the dynamic interconversion between the phosphorylated and non-phosphorylated isoforms of a protein.
学术搜索中的文章
X He, B Ma, Y Chen, J Guo, W Niu - Chemical Communications, 2022