作者
Maren Maanja, Björn Wieslander, Todd T Schlegel, Ljuba Bacharova, Hussein Abu Daya, Yaron Fridman, Timothy C Wong, Erik B Schelbert, Martin Ugander
发表日期
2017/1/22
期刊
Journal of the American Heart Association
卷号
6
期号
1
页码范围
e003795
简介
Background
Myocardial fibrosis quantified by myocardial extracellular volume fraction (ECV) and left ventricular mass (LVM) index (LVMI) measured by cardiovascular magnetic resonance might represent independent and opposing contributors to ECG voltage measures of left ventricular hypertrophy (LVH). Diffuse myocardial fibrosis can occur in LVH and interfere with ECG voltage measures. This phenomenon could explain the decreased sensitivity of LVH detectable by ECG, a fundamental diagnostic tool in cardiology.
Methods and Results
We identified 77 patients (median age, 53 [interquartile range, 26–60] years; 49% female) referred for contrast‐enhanced cardiovascular magnetic resonance with ECV measures and 12‐lead ECG. Exclusion criteria included clinical confounders that might influence ECG measures of LVH. We evaluated ECG voltage‐based LVH measures, including Sokolow‐Lyon index …
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M Maanja, B Wieslander, TT Schlegel, L Bacharova… - Journal of the American Heart Association, 2017