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Klebsiella pneumoniae is one of the main causes of urinary tract infections (UTIs). The uropathogens are becoming increasingly resistant to different classes of antibiotics and their resistance to new generations of cephalosporins due to the production of extended-spectrum beta-lactamases (ESBLs). The aim of this study was isolation K. pneumoniae from patients with UTI also investigates the antibiotic resistance patterns and determines their association with ESBL genes. CHROM agar Orientation medium was used for rapid detection of K. pneumoniae from urine specimens and the identification was confirmed by VITEK 2 system. Out of 77 of K. pneumoniae isolated from UTI patients, sixty-six (85.7 %) were considered ESBL producing based on phenotyping ESBL detection by ESBL E-strip test. These isolates were then tested by polymerase chain reaction (PCR) for the presence or absence of bla TEM, bla CTX …