作者
Farid Froghi, Fiammetta Soggiu, Federico Ricciardi, Kurinchi Gurusamy, Daniel S Martin, Jeshika Singh, Sulman Siddique, Christine Eastgate, Maria Ciaponi, Margaret McNeil, Helder Filipe, Otto Schwalowsky-Monks, Gretchelle Asis, Massimo Varcada, Brian R Davidson
发表日期
2019/10/1
期刊
BMJ open
卷号
9
期号
10
页码范围
e028783
出版商
British Medical Journal Publishing Group
简介
Introduction
Acute pancreatitis is an inflammatory disease of the pancreas with high risk of developing multiorgan failure and death. There are no effective pharmacological interventions used in current clinical practice. Maintaining fluid and electrolyte balance is the mainstay of supportive management. Goal-directed fluid therapy (GDFT) has been shown to decrease morbidity and mortality in surgical conditions with systemic inflammatory response. There is currently no randomised controlled trial (RCT) investigating the role of GDFT based on cardiac output parameters in patients with acute pancreatitis in the ward setting. A feasibility trial was designed to determine patient and clinician support for recruitment into an RCT of ward-based GDFT in acute pancreatitis, adherence to a GDFT protocol, safety, participant withdrawal, and to determine appropriate endpoints for a subsequent larger trial to evaluate efficacy …
学术搜索中的文章
F Froghi, F Soggiu, F Ricciardi, K Gurusamy, DS Martin… - BMJ open, 2019