作者
Ho-Kwong Li, Ines Rombach, Rhea Zambellas, A Sarah Walker, Martin A McNally, Bridget L Atkins, Benjamin A Lipsky, Harriet C Hughes, Deepa Bose, Michelle Kümin, Claire Scarborough, Philippa C Matthews, Andrew J Brent, Jose Lomas, Roger Gundle, Mark Rogers, Adrian Taylor, Brian Angus, Ivor Byren, Anthony R Berendt, Simon Warren, Fiona E Fitzgerald, Damien JF Mack, Susan Hopkins, Jonathan Folb, Helen E Reynolds, Elinor Moore, Jocelyn Marshall, Neil Jenkins, Christopher E Moran, Andrew F Woodhouse, Samantha Stafford, R Andrew Seaton, Claire Vallance, Carolyn J Hemsley, Karen Bisnauthsing, Jonathan AT Sandoe, Ila Aggarwal, Simon C Ellis, Deborah J Bunn, Rebecca K Sutherland, Gavin Barlow, Cushla Cooper, Claudia Geue, Nicola McMeekin, Andrew H Briggs, Parham Sendi, Elham Khatamzas, Tri Wangrangsimakul, TH Nicholas Wong, Lucinda K Barrett, Abtin Alvand, C Fraser Old, Jennifer Bostock, John Paul, Graham Cooke, Guy E Thwaites, Philip Bejon, Matthew Scarborough
发表日期
2019/1/31
期刊
New England Journal of Medicine
卷号
380
期号
5
页码范围
425-436
出版商
Massachusetts Medical Society
简介
Background
The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication.
Methods
We enrolled adults who were being treated for bone or joint infection at 26 U.K. centers. Within 7 days after surgery (or, if the infection was being managed without surgery, within 7 days after the start of antibiotic treatment), participants were randomly assigned to receive either intravenous or oral antibiotics to complete the first 6 weeks of therapy. Follow-on oral antibiotics were permitted in both groups. The primary end point was definitive treatment failure within 1 year after randomization. In the analysis of the risk of the primary end point, the noninferiority margin was 7.5 percentage points.
Results
Among the 1054 participants (527 in each group), end-point …
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HK Li, I Rombach, R Zambellas, AS Walker… - New England Journal of Medicine, 2019