查看文章

The purpose of this study was to evaluate the safety and feasibility of endovascular cooling during primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI).

In experimental models of AMI, mild systemic hypothermia has been shown to reduce metabolic demand and limit infarct size.

In a multi-center study, 42 patients with AMI (<6 h from symptom onset) were randomized to primary PCI with or without endovascular cooling (target core temperature 33°C). Cooling was maintained for 3 h after reperfusion. Skin warming, oral buspirone, and intravenous meperidine were used to reduce the shivering threshold. The primary end point was major adverse cardiac events at 30 days. Infarct size at 30 days was measured using ^99mTc-sestamibi SPECT imaging.

Endovascular cooling was performed successfully in 20 patients (95%). All achieved a core …