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PURPOSE: To estimate and compare the fractional distribution volume (fDV) of gadodiamide injection and technetium 99m–diethylenetriaminepentaacetic acid (DTPA) in the reperfused myocardium of rat hearts subjected to various durations of ischemia.

MATERIALS AND METHODS: Magnetic resonance (MR) imaging and autoradiography were performed in rats subjected to 20, 30, 40, or 60 minutes of regional ischemia followed by 1 hour of reperfusion. The fDVs of gadodiamide injection and ^99mTc-DTPA were measured and compared by using inversion-recovery echo-planar imaging and autoradiographic phosphor imaging, respectively.

RESULTS: The mean fDV of both tracers (gadodiamide and ^99mTc-DTPA) in normal myocardium was 18% ± 1, whereas that in the entire area at risk increased significantly (P < .05) with 20, 30, 40, and 60 minutes of ischemia to 32% ± 1, 57% ± 4, 66% ± 2, and 68 …