作者
Marcus VG Lacerda, Silvio CP Fragoso, Maria GC Alecrim, Márcia AA Alexandre, Belisa ML Magalhães, André M Siqueira, Luiz CL Ferreira, José R Araújo, Maria Paula G Mourão, Mireia Ferrer, Paola Castillo, Lorena Martin-Jaular, Carmen Fernandez-Becerra, Hernando del Portillo, Jaume Ordi, Pedro L Alonso, Quique Bassat
发表日期
2012/10/15
期刊
Clinical Infectious Diseases
卷号
55
期号
8
页码范围
e67-e74
出版商
Oxford University Press
简介
Background. Severe disease attributable to Plasmodium vivax infection is already well described worldwide; however, autopsies in these patients are scarce.
Methods. From 1996 to 2010, 19 patient deaths with a clinical diagnosis of P. vivax infection occurred in a tertiary care center in the Brazilian Amazon. Seventeen of these 19 deaths were fully autopsied. Clinical charts, macroscopic autopsy reports, and stored paraffinized tissue blocks were retrieved. Nested polymerase chain reaction was performed in paraffinized samples of spleen and lung to confirm P. vivax monoinfection. Immunohistofluorescence was used to detect P. vivax parasitized red blood cells (RBCs).
Results. Of 17 autopsies, 13 revealed that death could be attributed to P. vivax infection; in the remaining 4, acute diseases other than malaria were found to be the cause of …
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