作者
Andrée Yeramian, Lorena Martin, Luis Arpa, Joan Bertran, Concepció Soler, Carol McLeod, Manuel Modolell, Manuel Palacín, Jorge Lloberas, Antonio Celada
发表日期
2006/6
期刊
European journal of immunology
卷号
36
期号
6
页码范围
1516-1526
出版商
WILEY‐VCH Verlag
简介
In murine macrophages, as a result of arginine catabolism during activation, citruline is produced under the effect of IFN‐γ and LPS, and ornithine and polyamines by IL‐4 and IL‐10. For proliferation, arginine is required from the extracellular medium and is used for protein synthesis. During activation, most arginine (>95% in 6 h) was metabolized, while under proliferation only half was incorporated into proteins. Under basal conditions, this amino acid was preferentially transported by y+L activity. During activation, arginine transport increased drastically (4–5‐fold) through y+ cationic amino acid transporter (CAT) activity. By contrast, M‐CSF induced only a modest increase in uptake (0.5‐fold). The increase in arginine transport during activation, but not proliferation, was mediated by the SLC7A2/Cat2 gene. SLC7A1/Cat1 is constitutively expressed, and is not modified by proliferating or activating agents. M‐CSF …
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A Yeramian, L Martin, L Arpa, J Bertran, C Soler… - European journal of immunology, 2006