作者
Kwang-Hyun Hur, Seong-Eon Kim, Bo-Ram Lee, Yong-Hyun Ko, Jee-Yeon Seo, Seon-Kyung Kim, Shi-Xun Ma, Young-Jung Kim, Yeongdo Jeong, Duc Toan Pham, Quynh Dieu Trinh, Eun-Joo Shin, Hyoung-Chun Kim, Yong-Sup Lee, Seok-Yong Lee, Choon-Gon Jang
发表日期
2020/7
期刊
Archives of Toxicology
卷号
94
页码范围
2505-2516
出版商
Springer Berlin Heidelberg
简介
The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects. Considering that NPSs have caused unexpected harmful effects leading to emergency and even death, scientific confirmation of the potential adverse effects of 25C-NBF is essential. In the present study, we investigated whether 25C-NBF has addictive and neurotoxic potential and causes neurochemical changes. In addictive potential assessments, high conditioned place preference (CPP) scores and stable self-administration (SA) were observed in the 25C-NBF groups (CPP [3 mg kg−1]; SA [0.01, 0.03, 0.1 mg kg−1]), suggesting the addictive liability of 25C-NBF. In neurotoxic potential assessments …
引用总数
2020202120222023202414491
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