作者
Angelika Chachaj, Ivana Stanimirova, Mariusz Chabowski, Agnieszka Gomułkiewicz, Paweł Hodurek, Natalia Glatzel-Plucińska, Mateusz Olbromski, Aleksandra Piotrowska, Aleksandra Kuzan, Jędrzej Grzegrzółka, Katarzyna Ratajczak-Wielgomas, Aleksandra Nowak, Ewa Szahidewicz-Krupska, Jerzy Wiśniewski, Mariusz A Bromke, Marzenna Podhorska-Okołów, Andrzej Gamian, Dariusz Janczak, Piotr Dzięgiel, Andrzej Szuba
发表日期
2023/9/1
期刊
Advances in Medical Sciences
卷号
68
期号
2
页码范围
276-289
出版商
Elsevier
简介
Purpose
Recent studies, conducted mainly on the rodent model, have demonstrated that regulatory pathway in the skin provided by glycosaminoglycans, nuclear factor of activated T cells 5 (NFAT5), vascular endothelial growth factor C (VEGF-C) and process of lymphangiogenesis may play an important role in extrarenal regulation of sodium (Na+) balance, body water volume, and blood pressure. We aimed to investigate the concentrations and relations among the main factors of this pathway in human skin to confirm that this regulatory axis also exists in humans.
Patients and methods
Skin specimens from patients diagnosed with arterial hypertension and from control group were histologically and molecularly examined.
Results
The primary hypertensive and control groups did not differ in Na+ concentrations in the skin. However, the patients with hypertension and higher skin Na+ concentration had significantly …
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A Chachaj, I Stanimirova, M Chabowski… - Advances in Medical Sciences, 2023