作者
Andrew J Berger, Irving Itzkan, Michael S Feld
发表日期
1997/2/1
期刊
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
卷号
53
期号
2
页码范围
287-292
出版商
Elsevier
简介
We report the determinations of glucose concentration in human whole blood samples made using near-infrared Raman spectroscopy. Raman spectra of blood samples with above-physiological levels of glucose were acquired for 5 min through the wall of a cuvette via fiber optics. Partial least squares analysis was used to predict glucose concentrations in the samples. A root mean squared prediction error of 3.6 mM glucose was achieved with a correlation coefficient of 0.99 between reference and predicted values. This result is the first step in evaluating the potential of near-infrared Raman spectroscopy to perform blood glucose measurements with clinical accuracy. The technique is capable of measuring the concentration of other Raman-active blood constituents; as an example, bicarbonate was also measured. The method could eventually be useful for direct measurement of tissue analytes.
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AJ Berger, I Itzkan, MS Feld - Spectrochimica Acta Part A: Molecular and …, 1997