| Dimethyl sulfoxide has an impact on epigenetic profile in mouse embryoid body M Iwatani, K Ikegami, Y Kremenska, N Hattori, S Tanaka, S Yagi, K Shiota Stem cells 24 (11), 2549-2556, 2006 | 297 | 2006 |
| Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing S Araki, R Dairiki, Y Nakayama, A Murai, R Miyashita, M Iwatani, ... PloS one 10 (1), e0116929, 2015 | 135 | 2015 |
| A novel LSD1 inhibitor T-3775440 disrupts GFI1B-containing complex leading to transdifferentiation and impaired growth of AML cells Y Ishikawa, K Gamo, M Yabuki, S Takagi, K Toyoshima, K Nakayama, ... Molecular cancer therapeutics 16 (2), 273-284, 2017 | 107 | 2017 |
| Genome‐wide and locus‐specific DNA hypomethylation in G9a deficient mouse embryonic stem cells K Ikegami, M Iwatani, M Suzuki, M Tachibana, Y Shinkai, S Tanaka, ... Genes to Cells 12 (1), 1-11, 2007 | 103 | 2007 |
| Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability K Iwai, M Yaguchi, K Nishimura, Y Yamamoto, T Tamura, D Nakata, ... EMBO molecular medicine 10 (6), e8289, 2018 | 84 | 2018 |
| Structure-based discovery of cellular-active allosteric inhibitors of FAK N Tomita, Y Hayashi, S Suzuki, Y Oomori, Y Aramaki, Y Matsushita, ... Bioorganic & medicinal chemistry letters 23 (6), 1779-1785, 2013 | 63 | 2013 |
| CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor T Funnell, S Tasaki, A Oloumi, S Araki, E Kong, D Yap, Y Nakayama, ... Nature Communications 8 (1), 7, 2017 | 59 | 2017 |
| Discovery and characterization of novel allosteric FAK inhibitors M Iwatani, H Iwata, A Okabe, RJ Skene, N Tomita, Y Hayashi, Y Aramaki, ... European Journal of Medicinal Chemistry 61, 49-60, 2013 | 57 | 2013 |
| CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens T Ishii, T Okai, M Iwatani-Yoshihara, M Mochizuki, S Unno, M Kuno, ... Scientific reports 7 (1), 13000, 2017 | 55 | 2017 |
| Discovery and characterization of a eukaryotic initiation factor 4A-3-selective inhibitor that suppresses nonsense-mediated mRNA decay M Iwatani-Yoshihara, M Ito, Y Ishibashi, H Oki, T Tanaka, D Morishita, T Ito, ... ACS chemical biology 12 (7), 1760-1768, 2017 | 41 | 2017 |
| T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice S Matsuda, R Baba, H Oki, S Morimoto, M Toyofuku, S Igaki, Y Kamada, ... Neuropsychopharmacology 44 (8), 1505-1512, 2019 | 40 | 2019 |
| Discovery of allosteric inhibitors targeting the spliceosomal RNA helicase Brr2 M Iwatani-Yoshihara, M Ito, MG Klein, T Yamamoto, K Yonemori, ... Journal of Medicinal Chemistry 60 (13), 5759-5771, 2017 | 36 | 2017 |
| Discovery of novel 1, 4-diacylpiperazines as selective and cell-active eIF4A3 inhibitors M Ito, T Tanaka, DR Cary, M Iwatani-Yoshihara, Y Kamada, T Kawamoto, ... Journal of medicinal chemistry 60 (8), 3335-3351, 2017 | 35 | 2017 |
| Genome‐wide DNA methylation profile of tissue‐dependent and differentially methylated regions (T‐DMRs) residing in mouse pluripotent stem cells S Sato, S Yagi, Y Arai, K Hirabayashi, N Hattori, M Iwatani, K Okita, ... Genes to Cells 15 (6), 607-618, 2010 | 34 | 2010 |
| Discovery of selective ATP-competitive eIF4A3 inhibitors M Ito, M Iwatani, Y Kamada, S Sogabe, S Nakao, T Tanaka, T Kawamoto, ... Bioorganic & Medicinal Chemistry 25 (7), 2200-2209, 2017 | 32 | 2017 |
| Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos M Oda, S Tanaka, Y Yamazaki, H Ohta, M Iwatani, M Suzuki, J Ohgane, ... Proceedings of the National Academy of Sciences 106 (38), 16293-16297, 2009 | 27 | 2009 |
| Discovery of spiro [indole-3, 2′-pyrrolidin]-2 (1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP M Ito, M Iwatani, T Yamamoto, T Tanaka, T Kawamoto, D Morishita, ... Bioorganic & Medicinal Chemistry 25 (17), 4753-4767, 2017 | 25 | 2017 |
| Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation T Arita, M Morimoto, Y Yamamoto, H Miyashita, S Kitazawa, T Hirayama, ... Biochemical and biophysical research communications 488 (4), 648-654, 2017 | 17 | 2017 |
| Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors R Mizojiri, D Nakata, Y Satoh, D Morishita, S Shibata, ... ACS Medicinal Chemistry Letters 8 (10), 1077-1082, 2017 | 14 | 2017 |
| Design, synthesis, and structure–activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects Y Hattori, S Matsumoto, S Morimoto, M Daini, M Toyofuku, S Matsuda, ... European Journal of Medicinal Chemistry 239, 114522, 2022 | 13 | 2022 |
