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David Finlay
David Finlay
Postdoctoral Fellow, University of Otago
在 otago.ac.nz 的电子邮件经过验证 - 首页
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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
M Soethoudt, U Grether, J Fingerle, TW Grim, F Fezza, L De Petrocellis, ...
Nature communications 8 (1), 13958, 2017
3212017
Terpenoids from cannabis do not mediate an entourage effect by acting at cannabinoid receptors
DB Finlay, KJ Sircombe, M Nimick, C Jones, M Glass
Frontiers in pharmacology 11, 359, 2020
992020
s signalling of the CB1 receptor and the influence of receptor number
DB Finlay, EE Cawston, NL Grimsey, MR Hunter, A Korde, VK Vemuri, ...
British Journal of Pharmacology 174 (15), 2545-2562, 2017
912017
GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine
DB Finlay, WR Joseph, NL Grimsey, M Glass
PeerJ 4, e1835, 2016
852016
Cannabinoid CB1 and CB2 receptor-mediated arrestin translocation: species, subtype, and agonist-dependence
MS Ibsen, DB Finlay, M Patel, JA Javitch, M Glass, NL Grimsey
Frontiers in pharmacology 10, 350, 2019
782019
Do toxic synthetic cannabinoid receptor agonists have signature in vitro activity profiles? A case study of AMB-FUBINACA
DB Finlay, JJ Manning, MS Ibsen, CE Macdonald, M Patel, JA Javitch, ...
ACS chemical neuroscience 10 (10), 4350-4360, 2019
532019
Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists
M Patel, JJ Manning, DB Finlay, JA Javitch, SD Banister, NL Grimsey, ...
Biochemical Pharmacology 175, 113871, 2020
512020
100 years of modelling ligand–receptor binding and response: A focus on GPCRs
DB Finlay, SB Duffull, M Glass
British journal of pharmacology 177 (7), 1472-1484, 2020
512020
Biased agonism at the cannabinoid receptors–evidence from synthetic cannabinoid receptor agonists
M Patel, DB Finlay, M Glass
Cellular Signalling 78, 109865, 2021
352021
Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias
JJ Manning, HM Green, M Glass, DB Finlay
Neuropharmacology 193, 108611, 2021
302021
Model‐free and kinetic modelling approaches for characterising non‐equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors
X Zhu, DB Finlay, M Glass, SB Duffull
British Journal of Pharmacology 176 (14), 2593-2607, 2019
292019
Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling
X Zhu, DB Finlay, M Glass, SB Duffull
British journal of pharmacology 177 (15), 3449-3463, 2020
182020
Real-time measurement of cannabinoid receptor-mediated cAMP signaling
MR Hunter, DB Finlay, CE Macdonald, EE Cawston, NL Grimsey, M Glass
Methods in enzymology 593, 43-59, 2017
182017
In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018
TF Gamage, DG Barrus, RC Kevin, DB Finlay, TW Lefever, PR Patel, ...
Pharmacology Biochemistry and Behavior 193, 172918, 2020
172020
An evaluation of the operational model when applied to quantify functional selectivity
X Zhu, DB Finlay, M Glass, SB Duffull
British journal of pharmacology 175 (10), 1654-1668, 2018
172018
Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
M Haney, M Vallée, S Fabre, S Collins Reed, M Zanese, G Campistron, ...
Nature Medicine 29 (6), 1487-1499, 2023
152023
A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models
CA Mielnik, KS Sugamori, DB Finlay, HHA Thorpe, M Schapira, ...
Neuropsychopharmacology 46 (2), 413-422, 2021
112021
Defining Steric Requirements at CB1 and CB2 Cannabinoid Receptors Using Synthetic Cannabinoid Receptor Agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1 …
J Markham, E Sparkes, R Boyd, S Chen, JJ Manning, D Finlay, F Lai, ...
ACS Chemical Neuroscience 13 (8), 1281-1295, 2022
102022
Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence
JJ Manning, G Rawcliffe, DB Finlay, M Glass
British journal of pharmacology 180 (3), 369-382, 2023
92023
Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors; β‐arrestins and GPCR kinases
M Patel, C Matti, NL Grimsey, DF Legler, JA Javitch, DB Finlay, M Glass
British journal of pharmacology 179 (10), 2223-2239, 2022
92022
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