Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 ACM van Esbroeck, APA Janssen, AB Cognetta III, D Ogasawara, ... Science 356 (6342), 1084-1087, 2017 | 320 | 2017 |
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition D Ogasawara, H Deng, A Viader, MP Baggelaar, A Breman, H den Dulk, ... Proceedings of the National Academy of Sciences 113 (1), 26-33, 2016 | 170 | 2016 |
Highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons MP Baggelaar, PJP Chameau, V Kantae, J Hummel, KL Hsu, F Janssen, ... Journal of the American Chemical Society 137 (27), 8851-8857, 2015 | 94 | 2015 |
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice ED Mock, M Mustafa, O Gunduz-Cinar, R Cinar, GN Petrie, V Kantae, X Di, ... Nature chemical biology 16 (6), 667-675, 2020 | 72 | 2020 |
Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase α and α/β-Hydrolase Domain 6 FJ Janssen, H Deng, MP Baggelaar, M Allarà, T van der Wel, H den Dulk, ... Journal of Medicinal Chemistry 57 (15), 6610-6622, 2014 | 46 | 2014 |
Triazole ureas act as diacylglycerol lipase inhibitors and prevent fasting-induced refeeding H Deng, S Kooijman, AMCH van den Nieuwendijk, D Ogasawara, ... Journal of Medicinal Chemistry 60 (1), 428-440, 2017 | 43 | 2017 |
A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α T van Der Wel, FJ Janssen, MP Baggelaar, H Deng, H den Dulk, ... Journal of lipid research 56 (4), 927-935, 2015 | 43 | 2015 |
Development of high-specificity fluorescent probes to enable cannabinoid type 2 receptor studies in living cells RC Sarott, MV Westphal, P Pfaff, C Korn, DA Sykes, T Gazzi, B Brennecke, ... Journal of the American Chemical Society 142 (40), 16953-16964, 2020 | 39 | 2020 |
Identification of α, β-hydrolase domain containing protein 6 as a diacylglycerol lipase in neuro-2a cells ACM Van Esbroeck, V Kantae, X Di, T Van der Wel, H Den Dulk, ... Frontiers in molecular neuroscience 12, 286, 2019 | 27 | 2019 |
Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe T Gazzi, B Brennecke, K Atz, C Korn, D Sykes, G Forn-Cuni, P Pfaff, ... Chemical Science 13 (19), 5539-5545, 2022 | 19 | 2022 |
Comparative photoaffinity profiling of omega-3 signaling lipid probes reveals prostaglandin reductase 1 as a metabolic hub in human macrophages B Gagestein, JH Von Hegedus, JC Kwekkeboom, M Heijink, N Blomberg, ... Journal of the American Chemical Society 144 (41), 18938-18947, 2022 | 15 | 2022 |
Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors H Deng, T van der Wel, RJ van den Berg, AMCH van den Nieuwendijk, ... MedChemComm 8 (5), 982-988, 2017 | 13 | 2017 |
Structure–activity relationship studies of α-ketoamides as inhibitors of the phospholipase A and acyltransferase enzyme family J Zhou, ED Mock, K Al Ayed, X Di, V Kantae, L Burggraaff, AF Stevens, ... Journal of Medicinal Chemistry 63 (17), 9340-9359, 2020 | 12 | 2020 |
Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis T van der Wel, R Hilhorst, H den Dulk, T van den Hooven, NM Prins, ... Nature Communications 11 (1), 3216, 2020 | 11 | 2020 |
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence M Jiang, MCW Huizenga, JL Wirt, J Paloczi, A Amedi, RJ van den Berg, ... Nature Communications 14 (1), 8039, 2023 | 5 | 2023 |
Chemical proteomics reveals off-targets of the anandamide reuptake inhibitor WOBE437 B Gagestein, AF Stevens, D Fazio, BI Florea, T Van Der Wel, AT Bakker, ... ACS Chemical Biology 17 (5), 1174-1183, 2022 | 5 | 2022 |
Triazole DAGLα inhibitors BF Cravatt, D Ogasawara, A Viader, H Deng, T VAN DER WEL, ... US Patent 10,583,137, 2020 | 3 | 2020 |
Drug derived fluorescent probes for the specific visualization of cannabinoid type 2 receptor-a toolbox approach T Gazzi, B Brennecke, K Atz, C Korn, D Sykes, RC Sarott, MV Westphal, ... | 3 | 2019 |
Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta N Berger, T van der Wel, B Hirschmugl, T Baernthaler, J Gindlhuber, ... Frontiers in Endocrinology 14, 1092024, 2023 | 2 | 2023 |
Highly Specific, Fluorescent Cannabinoid Type 2 Receptor Probes Enable Applications in Microscopy, Flow Cytometry and FRET-based Binding Assays R Sarott, M Westphal, P Pfaff, C Korn, D Sykes, T Gazzi, B Brennecke, ... | 2 | 2019 |