| Detection of ultra-rare mutations by next-generation sequencing MW Schmitt, SR Kennedy, JJ Salk, EJ Fox, JB Hiatt, LA Loeb Proceedings of the National Academy of Sciences 109 (36), 14508-14513, 2012 | 1132 | 2012 |
| Detecting ultralow-frequency mutations by Duplex Sequencing SR Kennedy, MW Schmitt, EJ Fox, BF Kohrn, JJ Salk, EH Ahn, MJ Prindle, ... Nature protocols 9 (11), 2586-2606, 2014 | 540 | 2014 |
| Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage SR Kennedy, JJ Salk, MW Schmitt, LA Loeb PLoS genetics 9 (9), e1003794, 2013 | 412 | 2013 |
| Endogenous Parkin preserves dopaminergic substantia nigral neurons following mitochondrial DNA mutagenic stress AM Pickrell, CH Huang, SR Kennedy, A Ordureau, DP Sideris, ... Neuron 87 (2), 371-381, 2015 | 325 | 2015 |
| Somatic mutations in aging, cancer and neurodegeneration SR Kennedy, LA Loeb, AJ Herr Mechanisms of ageing and development 133 (4), 118-126, 2012 | 299 | 2012 |
| Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues JD Krimmel, MW Schmitt, MI Harrell, KJ Agnew, SR Kennedy, MJ Emond, ... Proceedings of the National Academy of Sciences 113 (21), 6005-6010, 2016 | 215 | 2016 |
| Aging and the rise of somatic cancer-associated mutations in normal tissues RA Risques, SR Kennedy PLoS genetics 14 (1), e1007108, 2018 | 208 | 2018 |
| Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations LS Itsara, SR Kennedy, EJ Fox, S Yu, JJ Hewitt, M Sanchez-Contreras, ... PLoS genetics 10 (2), e1003974, 2014 | 183 | 2014 |
| Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage JG Hoekstra, MJ Hipp, TJ Montine, SR Kennedy Annals of Neurology 80 (2), 301-306, 2016 | 99 | 2016 |
| A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster MR Patel, GK Miriyala, AJ Littleton, H Yang, K Trinh, JM Young, ... eLife 5, e16923, 2016 | 86 | 2016 |
| Nextgeneration genotoxicology: using modern sequencing technologies to assess somatic mutagenesis and cancer risk JJ Salk, SR Kennedy Environmental and Molecular Mutagenesis 61 (1), 135-151, 2020 | 79 | 2020 |
| DNA replication error-induced extinction of diploid yeast AJ Herr, SR Kennedy, GM Knowels, EM Schultz, BD Preston Genetics 196 (3), 677-691, 2014 | 63 | 2014 |
| Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS) D Nachmanson, S Lian, EK Schmidt, MJ Hipp, KT Baker, Y Zhang, ... Genome research 28 (10), 1589-1599, 2018 | 47 | 2018 |
| Cancer-associated mutations but no cancer: insights into the early steps of carcinogenesis and implications for early cancer detection SR Kennedy, Y Zhang, RA Risques Trends in cancer 5 (9), 531-540, 2019 | 44 | 2019 |
| Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma J Xu, E Reznik, HJ Lee, G Gundem, P Jonsson, J Sarungbam, A Bialik, ... eLife 8, e38986, 2019 | 40 | 2019 |
| Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ CL Samstag, JG Hoekstra, CH Huang, MJ Chaisson, RJ Youle, ... PLoS genetics 14 (11), e1007805, 2018 | 34 | 2018 |
| A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA M Sanchez-Contreras, MT Sweetwyne, BF Kohrn, KA Tsantilas, MJ Hipp, ... Nucleic Acids Research 49 (19), 11103-11118, 2021 | 31 | 2021 |
| Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila S Andreazza, CL Samstag, A Sanchez-Martinez, E Fernandez-Vizarra, ... Nature communications 10 (1), 3280, 2019 | 31 | 2019 |
| Mitochondrial DNA mutations are associated with ulcerative colitis preneoplasia but tend to be negatively selected in cancer KT Baker, D Nachmanson, S Kumar, MJ Emond, C Ussakli, TA Brentnall, ... Molecular Cancer Research 17 (2), 488-498, 2019 | 31 | 2019 |
| The complicated nature of somatic mtDNA mutations in aging M Sanchez-Contreras, SR Kennedy Frontiers in aging 2, 805126, 2022 | 26 | 2022 |
