Assessing mitochondrial dysfunction in cells MD Brand, DG Nicholls Biochemical Journal 435 (2), 297-312, 2011 | 2760 | 2011 |
Topology of superoxide production from different sites in the mitochondrial electron transport chain J St-Pierre, JA Buckingham, SJ Roebuck, MD Brand Journal of Biological Chemistry 277 (47), 44784-44790, 2002 | 1969 | 2002 |
Superoxide activates mitochondrial uncoupling proteins KS Echtay, D Roussel, J St-Pierre, MB Jekabsons, S Cadenas, JA Stuart, ... Nature 415 (6867), 96-99, 2002 | 1671 | 2002 |
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins MD Brand, C Affourtit, TC Esteves, K Green, AJ Lambert, S Miwa, ... Free Radical Biology and Medicine 37 (6), 755-767, 2004 | 1364 | 2004 |
The sites and topology of mitochondrial superoxide production MD Brand Experimental gerontology 45 (7-8), 466-472, 2010 | 1362 | 2010 |
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism: a novel regulatory mechanism altered in obesity D Bach, S Pich, FX Soriano, N Vega, B Baumgartner, J Oriola, ... Journal of Biological Chemistry 278 (19), 17190-17197, 2003 | 1073 | 2003 |
A hierarchy of ATP-consuming processes in mammalian cells F Buttgereit, MD Brand Biochemical Journal 312 (1), 163-167, 1995 | 1023 | 1995 |
Mitochondrial proton and electron leaks M Jastroch, AS Divakaruni, S Mookerjee, JR Treberg, MD Brand Essays in biochemistry 47, 53-67, 2010 | 995 | 2010 |
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3 MD Brand, TC Esteves Cell metabolism 2 (2), 85-93, 2005 | 995 | 2005 |
Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling MD Brand Free Radical Biology and Medicine 100, 14-31, 2016 | 979 | 2016 |
Uncoupling to survive? The role of mitochondrial inefficiency in ageing MD Brand Experimental gerontology 35 (6-7), 811-820, 2000 | 952 | 2000 |
Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions CL Quinlan, AL Orr, IV Perevoshchikova, JR Treberg, BA Ackrell, ... Journal of Biological Chemistry 287 (32), 27255-27264, 2012 | 742 | 2012 |
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean JC Clapham, JRS Arch, H Chapman, A Haynes, C Lister, GBT Moore, ... Nature 406 (6794), 415-418, 2000 | 739 | 2000 |
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes K Green, MD Brand, MP Murphy Diabetes 53 (suppl_1), S110-S118, 2004 | 734 | 2004 |
A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling KS Echtay, TC Esteves, JL Pakay, MB Jekabsons, AJ Lambert, ... The EMBO journal, 2003 | 711 | 2003 |
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates CL Quinlan, IV Perevoshchikova, M Hey-Mogensen, AL Orr, MD Brand Redox biology 1 (1), 304-312, 2013 | 625 | 2013 |
The causes and functions of mitochondrial proton leak MD Brand, LF Chien, EK Ainscow, DFS Rolfe, RK Porter Biochimica et Biophysica Acta (BBA)-Bioenergetics 1187 (2), 132-139, 1994 | 593 | 1994 |
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer JR Speakman, DA Talbot, C Selman, S Snart, JS McLaren, P Redman, ... Aging cell 3 (3), 87-95, 2004 | 579 | 2004 |
Superoxide production by NADH: ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane AJ Lambert, MD Brand Biochemical Journal 382 (2), 511-517, 2004 | 573 | 2004 |
Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH: ubiquinone oxidoreductase (complex I) AJ Lambert, MD Brand Journal of Biological Chemistry 279 (38), 39414-39420, 2004 | 569 | 2004 |