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Nicholas A. Meanwell
Nicholas A. Meanwell
在 bms.com 的电子邮件经过验证
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引用次数
引用次数
年份
Applications of fluorine in medicinal chemistry
EP Gillis, KJ Eastman, MD Hill, DJ Donnelly, NA Meanwell
Journal of medicinal chemistry 58 (21), 8315-8359, 2015
26342015
Synopsis of some recent tactical application of bioisosteres in drug design
NA Meanwell
Journal of medicinal chemistry 54 (8), 2529-2591, 2011
25352011
Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design
NA Meanwell
Journal of medicinal chemistry 61 (14), 5822-5880, 2018
14132018
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
M Gao, RE Nettles, M Belema, LB Snyder, VN Nguyen, RA Fridell, ...
Nature 465 (7294), 96-100, 2010
10972010
A survey of the role of noncovalent sulfur interactions in drug design
BR Beno, KS Yeung, MD Bartberger, LD Pennington, NA Meanwell
Journal of medicinal chemistry 58 (11), 4383-4438, 2015
5972015
Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety
NA Meanwell
Chemical research in toxicology 24 (9), 1420-1456, 2011
5222011
The expanding role of prodrugs in contemporary drug design and development
J Rautio, NA Meanwell, L Di, MJ Hageman
Nature reviews drug discovery 17 (8), 559-587, 2018
5082018
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding
PF Lin, W Blair, T Wang, T Spicer, Q Guo, N Zhou, YF Gong, HGH Wang, ...
Proceedings of the National Academy of Sciences 100 (19), 11013-11018, 2003
4772003
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
VK Gribkoff, JE Starrett, SI Dworetzky, P Hewawasam, CG Boissard, ...
Nature medicine 7 (4), 471-477, 2001
3412001
Metabolic and pharmaceutical aspects of fluorinated compounds
BM Johnson, YZ Shu, X Zhuo, NA Meanwell
Journal of Medicinal Chemistry 63 (12), 6315-6386, 2020
3212020
Discovery of 4-Benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806):  A Novel HIV-1 Attachment Inhibitor That …
T Wang, Z Zhang, OB Wallace, M Deshpande, H Fang, Z Yang, ...
Journal of medicinal chemistry 46 (20), 4236-4239, 2003
2802003
Hepatitis C virus inhibitors
C Bachand, M Belema, DH Deon, AC Good, J Goodrich, CA James, ...
257*2008
Identification of hepatitis C virus NS5A inhibitors
JA Lemm, D O'Boyle, M Liu, PT Nower, R Colonno, MS Deshpande, ...
Journal of virology 84 (1), 482-491, 2010
2412010
Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions
Q Guo, HT Ho, I Dicker, L Fan, N Zhou, J Friborg, T Wang, BV McAuliffe, ...
Journal of virology 77 (19), 10528-10536, 2003
2182003
Preclinical profile and characterization of the hepatitis C virus NS3 protease inhibitor asunaprevir (BMS-650032)
F McPhee, AK Sheaffer, J Friborg, D Hernandez, P Falk, G Zhai, S Levine, ...
Antimicrobial agents and chemotherapy 56 (10), 5387-5396, 2012
2162012
Effects of channel modulators on cloned large-conductance calcium-activated potassium channels.
VK Gribkoff, JT Lum-Ragan, CG Boissard, DJ Post-Munson, NA Meanwell, ...
Molecular pharmacology 50 (1), 206-217, 1996
2061996
Azetidin-2-one derivatives as inhibitors of thrombin
WT Han, AK Trehan, JJK Wright, ME Federici, SM Seiler, NA Meanwell
Bioorganic & Medicinal Chemistry 3 (8), 1123-1143, 1995
2051995
Synthesis and structure− activity relationships of 3-aryloxindoles: A new class of calcium-dependent, large conductance potassium (Maxi-K) channel openers with neuroprotective …
P Hewawasam, M Erway, SL Moon, J Knipe, H Weiner, CG Boissard, ...
Journal of medicinal chemistry 45 (7), 1487-1499, 2002
1932002
The synthesis and characterization of BMS-204352 (MaxiPost™) and related 3-fluorooxindoles as openers of maxi-K potassium channels
P Hewawasam, VK Gribkoff, Y Pendri, SI Dworetzky, NA Meanwell, ...
Bioorganic & medicinal chemistry letters 12 (7), 1023-1026, 2002
1782002
Improving drug design: an update on recent applications of efficiency metrics, strategies for replacing problematic elements, and compounds in nontraditional drug space
NA Meanwell
Chemical Research in Toxicology 29 (4), 564-616, 2016
1712016
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