Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes J Liu, JD Farmer Jr, WS Lane, J Friedman, I Weissman, SL Schreiber Cell 66 (4), 807-815, 1991 | 5130 | 1991 |
Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP Y Liu-Chittenden, B Huang, JS Shim, Q Chen, SJ Lee, RA Anders, JO Liu, ... Genes & development 26 (12), 1300-1305, 2012 | 1397 | 2012 |
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin T Schneider-Poetsch, J Ju, DE Eyler, Y Dang, S Bhat, WC Merrick, ... Nature chemical biology 6 (3), 209-217, 2010 | 1115 | 2010 |
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth H Zhang, DZ Qian, YS Tan, KA Lee, P Gao, YR Ren, S Rey, H Hammers, ... Proceedings of the National Academy of Sciences 105 (50), 19579-19586, 2008 | 726 | 2008 |
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth J Kim, JY Tang, R Gong, J Kim, JJ Lee, KV Clemons, CR Chong, ... Cancer cell 17 (4), 388-399, 2010 | 579 | 2010 |
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization KA Lee, H Zhang, DZ Qian, S Rey, JO Liu, GL Semenza Proceedings of the National Academy of Sciences 106 (42), 17910-17915, 2009 | 565 | 2009 |
Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin EC Griffith, Z Su, BE Turk, S Chen, YH Chang, Z Wu, K Biemann, JO Liu Chemistry & biology 4 (6), 461-471, 1997 | 551 | 1997 |
FK506 and ciclosporin: molecular probes for studying intracellular signal transduction J Liu Trends in pharmacological sciences 14 (5), 182-188, 1993 | 532 | 1993 |
XPB, a subunit of TFIIH, is a target of the natural product triptolide DV Titov, B Gilman, QL He, S Bhat, WK Low, Y Dang, M Smeaton, ... Nature chemical biology 7 (3), 182-188, 2011 | 489 | 2011 |
A three-hybrid system for detecting small ligand–protein receptor interactions EJ Licitra, JO Liu Proceedings of the National Academy of Sciences 93 (23), 12817-12821, 1996 | 488 | 1996 |
Recent advances in drug repositioning for the discovery of new anticancer drugs JS Shim, JO Liu International journal of biological sciences 10 (7), 654, 2014 | 398 | 2014 |
Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes Q Huai, HY Kim, Y Liu, Y Zhao, A Mondragon, JO Liu, H Ke Proceedings of the National Academy of Sciences 99 (19), 12037-12042, 2002 | 372 | 2002 |
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells F Pan, H Yu, EV Dang, J Barbi, X Pan, JF Grosso, D Jinasena, ... Science 325 (5944), 1142-1146, 2009 | 370 | 2009 |
The HBV drug entecavir—effects on HIV-1 replication and resistance MA McMahon, BL Jilek, TP Brennan, L Shen, Y Zhou, M Wind-Rotolo, ... New England Journal of Medicine 356 (25), 2614-2621, 2007 | 368 | 2007 |
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1α S Galbán, Y Kuwano, R Pullmann Jr, JL Martindale, HH Kim, A Lal, ... Molecular and cellular biology 28 (1), 93-107, 2008 | 366 | 2008 |
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B H He, Y Dang, F Dai, Z Guo, J Wu, X She, Y Pei, Y Chen, W Ling, C Wu, ... Journal of Biological Chemistry 278 (31), 29278-29287, 2003 | 365 | 2003 |
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells KA Lee, DZ Qian, S Rey, H Wei, JO Liu, GL Semenza Proceedings of the National Academy of Sciences 106 (7), 2353-2358, 2009 | 351 | 2009 |
Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 HD Youn, L Sun, R Prywes, JO Liu Science 286 (5440), 790-793, 1999 | 349 | 1999 |
A clinical drug library screen identifies astemizole as an antimalarial agent CR Chong, X Chen, L Shi, JO Liu, DJ Sullivan Jr Nature chemical biology 2 (8), 415-416, 2006 | 347 | 2006 |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma DK Jiang, J Sun, G Cao, Y Liu, D Lin, YZ Gao, WH Ren, XD Long, ... Nature genetics 45 (1), 72-75, 2013 | 346 | 2013 |