| Discovery of ARD-69 as a highly potent proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) for the treatment of prostate cancer X Han, C Wang, C Qin, W Xiang, E Fernandez-Salas, CY Yang, M Wang, ... Journal of medicinal chemistry 62 (2), 941-964, 2019 | 341 | 2019 |
| Discovery of MD-224 as a first-in-class, highly potent, and efficacious proteolysis targeting chimera murine double minute 2 degrader capable of achieving complete and durable … Y Li, J Yang, A Aguilar, D McEachern, S Przybranowski, L Liu, CY Yang, ... Journal of medicinal chemistry 62 (2), 448-466, 2018 | 244 | 2018 |
| Discovery of highly potent and efficient PROTAC degraders of androgen receptor (AR) by employing weak binding affinity VHL E3 ligase ligands X Han, L Zhao, W Xiang, C Qin, B Miao, T Xu, M Wang, CY Yang, ... Journal of medicinal chemistry 62 (24), 11218-11231, 2019 | 177 | 2019 |
| Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment S Kregel, C Wang, X Han, L Xiao, E Fernandez-Salas, P Bawa, ... Neoplasia 22 (2), 111-119, 2020 | 124 | 2020 |
| Discovery of ARD-2585 as an exceptionally potent and orally active PROTAC degrader of androgen receptor for the treatment of advanced prostate cancer W Xiang, L Zhao, X Han, C Qin, B Miao, D McEachern, Y Wang, ... Journal of medicinal chemistry 64 (18), 13487-13509, 2021 | 96 | 2021 |
| C3‐Symmetrical Cinchonine‐Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition C Min, X Han, Z Liao, X Wu, HB Zhou, C Dong Advanced Synthesis & Catalysis 353 (14‐15), 2715-2720, 2011 | 94 | 2011 |
| Applications of chiral squaramides: From asymmetric organocatalysis to biologically active compounds X Han, HB Zhou, C Dong The Chemical Record 16 (2), 897-906, 2016 | 82 | 2016 |
| C3‐Symmetric Cinchonine‐Squaramide‐Catalyzed Asymmetric Chlorolactonization of Styrene‐Type Carboxylic Acids with 1,3‐Dichloro‐5,5‐dimethylhydantoin … X Han, C Dong, HB Zhou Advanced Synthesis & Catalysis 356 (6), 1275-1280, 2014 | 71 | 2014 |
| A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo L Zhao, X Han, J Lu, D McEachern, S Wang Neoplasia 22 (10), 522-532, 2020 | 63 | 2020 |
| Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non-racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable … X Han, W Ouyang, B Liu, W Wang, P Tien, S Wu, HB Zhou Organic & Biomolecular Chemistry 11 (48), 8463-8475, 2013 | 54 | 2013 |
| Highly enantioselective Michael addition of 1, 3-dicarbonyl compounds to nitroalkenes catalyzed by designer chiral BINOL–quinine–squaramide: efficient access to optically … B Liu, X Han, Z Dong, H Lv, HB Zhou, C Dong Tetrahedron: Asymmetry 24 (20), 1276-1280, 2013 | 48 | 2013 |
| Bisperoxovandium (pyridin‐2‐squaramide) targets both PTEN and ERK1/2 to confer neuroprotection ZF Zhang, J Chen, X Han, Y Zhang, HB Liao, RX Lei, Y Zhuang, ZF Wang, ... British journal of pharmacology 174 (8), 641-656, 2017 | 44 | 2017 |
| Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors X Han, H Wu, W Wang, C Dong, P Tien, S Wu, HB Zhou Organic & Biomolecular Chemistry 12 (41), 8308-8317, 2014 | 43 | 2014 |
| Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel–Crafts reaction of indoles with alkyl trifluoropyruvate X Han, B Liu, HB Zhou, C Dong Tetrahedron: Asymmetry 23 (18-19), 1332-1337, 2012 | 42 | 2012 |
| PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective X Han, W Wei, Y Sun Acta materia medica 1 (2), 244, 2022 | 34 | 2022 |
| Strategies for the discovery of oral PROTAC degraders aimed at cancer therapy X Han, Y Sun Cell Reports Physical Science 3 (10), 2022 | 31 | 2022 |
| Targeting androgen receptor degradation with PROTACs from bench to bedside X Jia, X Han Biomedicine & Pharmacotherapy 158, 114112, 2023 | 24 | 2023 |
| An expedient approach to highly enantioenriched cyclic nitrones mediated by robust and recoverable C 3-symmetric cinchonine-squaramide catalysts X Han, X Wu, C Min, HB Zhou, C Dong RSC advances 2 (19), 7501-7505, 2012 | 23 | 2012 |
| Halolactones are potent HIV-1 non-nucleoside reverse transcriptase inhibitors X Han, H Wu, C Dong, P Tien, W Xie, S Wu, HB Zhou RSC advances 5 (13), 10005-10013, 2015 | 21 | 2015 |
| Identification and structure–activity relationships of diarylhydrazides as novel potent and selective human enterovirus inhibitors X Han, N Sun, H Wu, D Guo, P Tien, C Dong, S Wu, HB Zhou Journal of Medicinal Chemistry 59 (5), 2139-2150, 2016 | 19 | 2016 |
