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Miklós Békés
Miklós Békés
Arvinas, Inc
在 arvinas.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
PROTAC targeted protein degraders: the past is prologue
M Békés, DR Langley, CM Crews
Nature Reviews Drug Discovery 21 (3), 181-200, 2022
13682022
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ...
Science advances 6 (42), eabd4596, 2020
3462020
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
J Mikolajczyk, M Drag, M Békés, JT Cao, Z Ronai, GS Salvesen
Journal of Biological Chemistry 282 (36), 26217-26224, 2007
1972007
Deubiquitinases as a signaling target of oxidative stress
XM Cotto-Rios, M Békés, J Chapman, B Ueberheide, TT Huang
Cell reports 2 (6), 1475-1484, 2012
1632012
Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase
JR Horton, K Liebert, M Bekes, A Jeltsch, X Cheng
Journal of molecular biology 358 (2), 559-570, 2006
1462006
Recognition of Lys48-linked di-ubiquitin and deubiquitinating activities of the SARS coronavirus papain-like protease
M Békés, R Ekkebus, H Ovaa, TT Huang, CD Lima
Molecular cell 62 (4), 572-585, 2016
1442016
Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design
W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ...
biorxiv, 2020.04. 29.068890, 2020
1142020
The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases
M Békés, J Prudden, T Srikumar, B Raught, MN Boddy, GS Salvesen
Journal of Biological Chemistry 286 (12), 10238-10247, 2011
962011
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1
S Zhu, J Goeres, KM Sixt, M Békés, XD Zhang, GS Salvesen, MJ Matunis
Molecular cell 33 (5), 570-580, 2009
902009
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases
VE Albrow, EL Ponder, D Fasci, M Békés, E Deu, GS Salvesen, M Bogyo
Chemistry & biology 18 (6), 722-732, 2011
762011
The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway
KI Piatkov, L Colnaghi, M Békés, A Varshavsky, TT Huang
Molecular cell 48 (6), 926-933, 2012
742012
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
M Drag, J Mikolajczyk, M Bekes, FE Reyes-Turcu, JA Ellman, ...
Biochemical Journal 415 (3), 367-375, 2008
732008
SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme
M Békés, W Rut, P Kasperkiewicz, MPC Mulder, H Ovaa, M Drag, ...
Biochemical Journal 468 (2), 215-226, 2015
682015
Synthetic substrates for measuring activity of autophagy proteases-autophagins (Atg4) Autophagins (Atg4)
CW Shu, M Drag, M Bekes, D Zhai, GS Salvesen, JC Reed
Autophagy 6 (7), 936-947, 2010
592010
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors
EL Ponder, VE Albrow, BA Leader, M Békés, J Mikolajczyk, UP Fonović, ...
Chemistry & biology 18 (6), 711-721, 2011
552011
Engineered hybrid dimers: tracking the activation pathway of caspase-7
JB Denault, M Békés, FL Scott, KMB Sexton, M Bogyo, GS Salvesen
Molecular cell 23 (4), 523-533, 2006
522006
SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
KE Coleman, M Bekes, JR Chapman, SB Crist, MJK Jones, ...
Elife 6, e24325, 2017
492017
DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells
M Békés, K Okamoto, SB Crist, MJ Jones, JR Chapman, BB Brasher, ...
Cell reports 5 (3), 826-838, 2013
452013
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
S Patchett, Z Lv, W Rut, M Bekes, M Drag, SK Olsen, TT Huang
Cell Reports 36 (13), 2021
392021
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
W Rut, M Zmudzinski, SJ Snipas, M Bekes, TT Huang, M Drag
Chemical Science 11 (23), 6058-6069, 2020
282020
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