| Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration E Nicolaides, M Symillides, JB Dressman, C Reppas Pharmaceutical research 18, 380-388, 2001 | 273 | 2001 |
| An In Vitro Methodology for Forecasting Luminal Concentrations and Precipitation of Highly Permeable Lipophilic Weak Bases in the Fasted Upper Small Intestine D Psachoulias, M Vertzoni, J Butler, D Busby, M Symillides, J Dressman, ... Pharmaceutical research 29, 3486-3498, 2012 | 99 | 2012 |
| Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers M Vertzoni, C Markopoulos, M Symillides, C Goumas, G Imanidis, ... Molecular pharmaceutics 9 (5), 1189-1198, 2012 | 80 | 2012 |
| Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools B Hens, J Brouwers, B Anneveld, M Corsetti, M Symillides, M Vertzoni, ... European journal of pharmaceutical sciences 63, 233-242, 2014 | 75 | 2014 |
| In vitro versus canine data for predicting input profiles of isosorbide-5-mononitrate from oral extended release products on a confidence interval basis N Fotaki, M Symillides, C Reppas European journal of pharmaceutical sciences 24 (1), 115-122, 2005 | 74 | 2005 |
| Effect of elevated viscosity in the upper gastrointestinal tract on drug absorption in dogs C Reppas, G Eleftheriou, P Macheras, M Symillides, JB Dressman European journal of pharmaceutical sciences 6 (2), 131-139, 1998 | 74 | 1998 |
| The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review C Pentafragka, M Symillides, M McAllister, J Dressman, M Vertzoni, ... Journal of Pharmacy and Pharmacology 71 (4), 557-580, 2019 | 71 | 2019 |
| Bioequivalence of highly variable drugs: a comparison of the newly proposed regulatory approaches by FDA and EMA V Karalis, M Symillides, P Macheras Pharmaceutical research 29, 1066-1077, 2012 | 69 | 2012 |
| An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: design, implementation, and evaluation A Kourentas, M Vertzoni, N Stavrinoudakis, A Symillidis, J Brouwers, ... European Journal of Pharmaceutical Sciences 82, 106-114, 2016 | 64 | 2016 |
| Toward a quantitative approach for the prediction of the fraction of dose absorbed using the absorption potential concept PE Macheras, MY Symillides Biopharmaceutics & drug disposition 10 (1), 43-53, 1989 | 57 | 1989 |
| Biorelevant media for transport experiments in the Caco-2 model to evaluate drug absorption in the fasted and the fed state and their usefulness C Markopoulos, F Thoenen, D Preisig, M Symillides, M Vertzoni, N Parrott, ... European Journal of Pharmaceutics and Biopharmaceutics 86 (3), 438-448, 2014 | 55 | 2014 |
| Canine versus in vitro data for predicting input profiles of l-sulpiride after oral administration N Fotaki, M Symillides, C Reppas European journal of pharmaceutical sciences 26 (3-4), 324-333, 2005 | 52 | 2005 |
| Novel scaled average bioequivalence limits based on GMR and variability considerations V Karalis, M Symillides, P Macheras Pharmaceutical research 21, 1933-1942, 2004 | 47 | 2004 |
| Geometric mean ratio-dependent scaled bioequivalence limits with leveling-off properties V Karalis, P Macheras, M Symillides European journal of pharmaceutical sciences 26 (1), 54-61, 2005 | 42 | 2005 |
| Novel scaled bioequivalence limits with leveling-off properties J Kytariolos, V Karalis, P Macheras, M Symillides Pharmaceutical research 23, 2657-2664, 2006 | 39 | 2006 |
| Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products–a PEARRL review M Guimarães, M Statelova, R Holm, C Reppas, M Symilllides, M Vertzoni, ... Journal of Pharmacy and Pharmacology 71 (4), 603-642, 2019 | 37 | 2019 |
| The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration A Kourentas, M Vertzoni, V Barmpatsalou, P Augustijns, S Beato, J Butler, ... The AAPS journal 20, 1-12, 2018 | 36 | 2018 |
| Comparison of simulated cumulative drug versus time data sets with indices M Vertzoni, M Symillides, A Iliadis, E Nicolaides, C Reppas European journal of pharmaceutics and biopharmaceutics 56 (3), 421-428, 2003 | 36 | 2003 |
| An improved intercept method for the assessment of absorption rate in bioequivalence studies P Macheras, M Symillides, C Reppas Pharmaceutical research 13, 1755-1758, 1996 | 36 | 1996 |
| The cutoff time point of the partial area method for assessment of rate of absorption in bioequivalence studies P Macheras, M Symillides, C Reppas Pharmaceutical research 11, 831-834, 1994 | 36 | 1994 |
