DNAJ Proteins in neurodegeneration: essential and protective factors C Zarouchlioti, DA Parfitt, W Li, LM Gittings, ME Cheetham Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018 | 117 | 2018 |
C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A TG Moens, T Niccoli, KM Wilson, ML Atilano, N Birsa, LM Gittings, ... Acta Neuropathologica 137, 487-500, 2019 | 112 | 2019 |
The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis A Bampton, LM Gittings, P Fratta, T Lashley, A Gatt Acta Neuropathologica 140 (5), 599-623, 2020 | 79 | 2020 |
Hypertonic stress causes cytoplasmic translocation of neuronal, but not astrocytic, FUS due to impaired transportin function EM Hock, Z Maniecka, M Hruska-Plochan, S Reber, F Laferrière, SS MK, ... Cell reports 24 (4), 987-1000. e7, 2018 | 54 | 2018 |
Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity LM Gittings, S Boeynaems, D Lightwood, A Clargo, S Topia, L Nakayama, ... Acta neuropathologica 139, 407-410, 2020 | 37 | 2020 |
Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS LM Gittings, SC Foti, BC Benson, P Gami-Patel, AM Isaacs, T Lashley Acta neuropathologica communications 7, 1-13, 2019 | 33 | 2019 |
Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies LM Gittings, R Sattler Faculty reviews 9, 2020 | 27 | 2020 |
Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum LM Gittings, EB Alsop, J Antone, M Singer, TG Whitsett, R Sattler, ... Acta neuropathologica 146 (3), 433-450, 2023 | 12 | 2023 |
Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system E Bolukbasi, NS Woodling, DK Ivanov, J Adcott, A Foley, A Rajasingam, ... Proceedings of the National Academy of Sciences 118 (8), e2011491118, 2021 | 12 | 2021 |
Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features I Lorenzini, E Alsop, J Levy, LM Gittings, D Lall, BE Rabichow, S Moore, ... Frontiers in cellular neuroscience 17, 1179796, 2023 | 9 | 2023 |
Activated iPSC-microglia from C9orf72 ALS/FTD patients exhibit endosomal-lysosomal dysfunction I Lorenzini, E Alsop, J Levy, LM Gittings, BE Rabichow, D Lall, S Moore, ... BioRxiv, 2020.09. 03.277459, 2020 | 8 | 2020 |
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits RK Godfrey, E Alsop, RT Bjork, BS Chauhan, HC Ruvalcaba, J Antone, ... Acta neuropathologica communications 11 (1), 168, 2023 | 1 | 2023 |
Cellular and molecular phenotypes of C9orf72 ALS/FTD patient derived iPSC-microglia mono-cultures I Lorenzini, E Alsop, J Levy, LM Gittings, D Lall, BE Rabichow, S Moore, ... | 1 | 2020 |
The expression and presence of RNA binding proteins in FTLD-TDP SC Foti, LM Gittings, CE Toomey, YA Asi, T Lashley NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 45, 49-49, 2019 | | 2019 |
In vitro and pathological investigation of dipeptide repeat proteins in C9orf72 linked frontotemporal dementia and amyotrophic lateral sclerosis LM Gittings UCL (University College London), 2018 | | 2018 |
Heterogeneous nuclear ribonucleoprotein R in frontotemporal lobar degeneration L Gittings, B Benson, A Issacs, T Lashley NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 44, 31-31, 2018 | | 2018 |