Nucleic acids in chemistry and biology GM Blackburn Royal Society of Chemistry, 2006 | 1336 | 2006 |
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design RJ Russell, LF Haire, DJ Stevens, PJ Collins, YP Lin, GM Blackburn, ... Nature 443 (7107), 45-49, 2006 | 986 | 2006 |
Clodronate and liposome‐encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′‐(β, γ‐dichloromethylene) triphosphate, by mammalian cells in vitro JC Frith, J Mönkkönen, GM Blackburn, RGG Russell, MJ Rogers Journal of Bone and Mineral Research 12 (9), 1358-1367, 1997 | 620 | 1997 |
Structure and catalytic mechanism of the human histone methyltransferase SET7/9 B Xiao, C Jing, JR Wilson, PA Walker, N Vasisht, G Kelly, S Howell, ... Nature 421 (6923), 652-656, 2003 | 469 | 2003 |
Uracil-DNA glycosylase–DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects SS Parikh, G Walcher, GD Jones, G Slupphaug, HE Krokan, ... Proceedings of the National Academy of Sciences 97 (10), 5083-5088, 2000 | 314 | 2000 |
Crystal structure and functional analysis of the histone methyltransferase SET7/9 JR Wilson, C Jing, PA Walker, SR Martin, SA Howell, GM Blackburn, ... Cell 111 (1), 105-115, 2002 | 285 | 2002 |
Uracil-DNA glycosylase acts by substrate autocatalysis AR Dinner, GM Blackburn, M Karplus Nature 413 (6857), 752-755, 2001 | 267 | 2001 |
The synthesis and metal binding characteristics of novel, isopolar phosphonate analogues of nucleotides GM Blackburn, DE Kent, F Kolkmann Journal of the Chemical Society, Perkin Transactions 1, 1119-1125, 1984 | 264 | 1984 |
Phosphonates as analogues of biological phosphates GM Blackburn | 199 | 1981 |
Why did Nature select phosphate for its dominant roles in biology? MW Bowler, MJ Cliff, JP Waltho, GM Blackburn New Journal of Chemistry 34 (5), 784-794, 2010 | 193 | 2010 |
Genetic, biochemical, and crystallographic characterization of Fhit–substrate complexes as the active signaling form of Fhit HC Pace, PN Garrison, AK Robinson, LD Barnes, A Draganescu, ... Proceedings of the National Academy of Sciences 95 (10), 5484-5489, 1998 | 183 | 1998 |
The mechanism of the aminolysis of methyl formate GM Blackburn, WP Jencks Journal of the American Chemical Society 90 (10), 2638-2645, 1968 | 182 | 1968 |
Monofluoro-and difluoro-methylenebisphosphonic acids: isopolar analogues of pyrophosphoric acid GM Blackburn, DA England, F Kolkmann Journal of the Chemical Society, Chemical Communications, 930-932, 1981 | 172 | 1981 |
Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes MJ Rogers, RJ Brown, V Hodkin, GM Blackburn, RGG Russell, DJ Watts Biochemical and biophysical research communications 224 (3), 863-869, 1996 | 152 | 1996 |
Toward antibody-directed" abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing. P Wentworth, A Datta, D Blakey, T Boyle, LJ Partridge, GM Blackburn Proceedings of the National Academy of Sciences 93 (2), 799-803, 1996 | 152 | 1996 |
Antibiotic recognition by binuclear metallo-β-lactamases revealed by X-ray crystallography J Spencer, J Read, RB Sessions, S Howell, GM Blackburn, SJ Gamblin Journal of the American Chemical Society 127 (41), 14439-14444, 2005 | 151 | 2005 |
Synthesis of α-and γ-fluoroalkylphosphonates GM Blackburn, DE Kent Journal of the Chemical Society, Perkin Transactions 1, 913-917, 1986 | 143 | 1986 |
Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum MJ Rogers, X Ji, RGG Russell, GM Blackburn, MP Williamson, AV Bayless, ... Biochemical Journal 303 (1), 303-311, 1994 | 139 | 1994 |
Derivatives of tamoxifen. Dependence of antiestrogenicity on the 4-substituent R McCague, G Leclercq, N Legros, J Goodman, GM Blackburn, M Jarman, ... Journal of medicinal chemistry 32 (12), 2527-2533, 1989 | 117 | 1989 |
Isopolar vs isosteric phosphonate analogues of nucleotides GM Blackburn, F Eckstein, DE Kent, TD Perrée Nucleosides, Nucleotides & Nucleic Acids 4 (1-2), 165-167, 1985 | 111 | 1985 |